SLC40A1 and pantothenate kinase-associated neurodegeneration: As we suggested previously (Poli et al., 2010), defects in PANK2 in these type of cells could result in modification of expression of iron-related proteins, and particularly of ferroportin, the sole cellular iron exporter (Ganz, 2005), and hence shift iron homeostasis in brain toward iron accumulation, one of the main neuropathological feature of PKAN disorder.