As shown in the subgroup analysis based on TILs site, a poor prognosis for RFS in patients with breast cancer was shown by the detection of FOXP3+ TILs in Intratumoural and Peritumoral, but not in Total (Intratumoural: HR = 1.983, 95 % CI [1.232, 3.190], I2 = 44.7 %; Peritumoral: HR = 2.206, 95 % CI [1.287, 3.781], I = 0.0 %; Total: HR = 1.312, 95 % CI [0.580, 2.969], I2 = 79.8 %). Here, FOXP3 is linked to breast cancer.