Thus, we aimed to examine the expression of EG-VEGF, PKR1, and PKR2 in a large number of ACC, adrenocortical adenomas (ACA), and normal adrenal glands (NAG) using real-time PCR (NAG, n = 12; ACA, n = 24 (cortisol-producing adenoma, n = 8; aldosterone-producing adenoma, n = 8; endocrine-inactive adenoma, n = 8); and ACC, n = 30) and immunohistochemistry (NAG, n = 9; ACA, n = 23 (cortisol-producing adenoma, n = 8; aldosterone-producing adenoma, n = 8; endocrine-inactive adenoma, n = 7); and ACC, n = 163). This evidence concerns the gene PROKR1 and adrenal cortex carcinoma.