Multivariate regression analysis including age, sex, and ENSAT tumor stage confirmed the independent prognostic value of this combination (EG-VEGF: HR 2.41, 95 % CI 1.08–5.38, p = 0.03; PKR1: HR 1.95, 95 % CI 1.06–3.56, p = 0.03; EG-VEGF or PKR1: HR 5.15, 95 % CI 1.24–21.36, p = 0.02) (Table 4). Here, PROKR1 is linked to neoplasm.