Pro-inflammatory macrophages in the colon of patients with Crohn’s disease express CD14, produce inflammatory mediators in response to Toll-Like Receptor (TLR) stimulation and contribute to chronic intestinal inflammation via induction of the interleukin-23/interferon-γ (IL-23/IFN-γ)–positive feedback loop [29]. The gene discussed is IL37; the disease is Crohn disease.