To examine the possible status of these cells in the pathophysiology of CC, we measured the frequency of peripheral Th22, Th17, Th1, mRNA expression levels of RORC, AHR, IL-6, TNF-α in PBMCs along with plasma concentrations of IL-22, IL-17 and TNF-α in PB of CC, CIN patients and HC for assessing their relevance. The gene discussed is TNF; the disease is cervical squamous intraepithelial neoplasia.