Several of these enzymes have been known to be involved in various genetic disorders such as Sotos syndrome and Wolf–Hirschhorn syndrome related to translocation of several members of the NSD family of H3K36 methyltransferases 153, 154, 155, and cancers related to translocation or mutation of MLL, NSD2, PRC2, SETD2, and countless others 156, 157, 158. This evidence concerns the gene NSD2 and Sotos syndrome.