With this in mind, we aimed to (1) evaluate the basal levels of Bcl-2 and Beclin-1 in HeLa and CaSki cell lines, (2) silence Bcl-2 as a means of defining its role during cisplatin treatment, and finally analyse pre-malignant low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), as well as malignant cervical tissue for the presence of Bcl-2 under basal conditions in order to evaluate its possible role in vivo during the progression of cervical cancer and validate the in vitro results. The gene discussed is BECN1; the disease is squamous cell intraepithelial neoplasia.