GABARAPL1 and breast cancer: Since tumors are frequently associated with aberrant DNA methylation content, we quantified global DNA methylation levels using ELISA in gDNA issued from both grade III BC samples (associated with the lowest expression of GABARAPL1 mRNA, as previously described in Fig. 1 and NT tissues (Fig. 2a).7 [25, 26] As expected, several gDNA issued from grade III BC presented a lower global DNA methylation compared to gDNA issued from NT tissues.