We report here that the GABARAPL1 gene is highly methylated in both–600 (MC1) and +200 (MC2) promoter regions but the 5′-UTR +200 region presents the more significant difference between non tumoral tissues/cells promoter regions and tumoral/cancer cells since this region is poorly methylated in normal tissue and frequently methylated in tumors (Fig. 2). The gene discussed is GABARAPL1; the disease is cancer.