The total WBC counts for unmutated IGVH (U-CLL) were higher than mutated IGVH (M-CLL) specimens (Table 1) and the U-CLL specimens were noted to have a higher percentage of leukemic cells expressing CD38 and Zap-70 as described before [4, 5]. Here, ZAP70 is linked to B-cell chronic lymphocytic leukemia.