FOS (# 111), JUN (#152), DSP (desmoplakin #2), TRIB2 (Tribbles homolog 2, #66) and DUSP1 (dual specificity phosphatase 1 # 49) were selected from the set of genes that have a lower expression in CLL specimens than B cells (Table 2, Additional file 3, # represent the position of the gene based on the FPKM data, lower number corresponds to higher down regulation). The gene discussed is FOS; the disease is B-cell chronic lymphocytic leukemia.