For down regulated genes in CLL, only DSP and TRIB2 expression is significantly lower (p < 0.5) as compared to B cells, while in the set of up-regulated genes, the expression of SELPG, AMICA, TYROBP and LEF1 is significantly higher (p < 0.5) in the test cohort. This evidence concerns the gene LEF1 and B-cell chronic lymphocytic leukemia.