In the current study, we have used flow cytometry and q-Real-time-PCR to evaluate EpCAM expression in primary carcinosarcomas cell lines and explored for the first time the potential of solitomab, an EpCAM/CD3 BiTE®, as a novel therapeutic strategy against carcinosarcoma cell lines and un-manipulated malignant tumor cells isolated from malignant pleural fluid of a patient. The gene discussed is EPCAM; the disease is cancer.