(note: In the present study the hybridized probes of FISH test included RB-1,TP53, Bcr/abL, PML/RARA, AML1/ETO, MLL, FGFR1, CBFB, TET/AML, Bcl-2, MYC, CCND1/IgH; of those negative bio-markers did not listed). The gene discussed is PML; the disease is acute myeloid leukemia.