Of interest, dapagliflozin 10 mg treatment significantly improved glycemic control and reduced body weight both in 151 early-stage and in 58 late-stage patients with T2DM, reflecting the usefulness of dapagliflozin as monotherapy in patients in the early stage of T2DM, and as add-on or combination therapy in late-stage patients on high doses of insulin plus oral insulin sensitizers [60]. This evidence concerns the gene INS and type 2 diabetes mellitus.