Moreover, another recent follow-up study replicated four of the PCOS susceptibility loci (DENND1A, THADA, FSHR and INSR) in a cohort of European population, and the risk score analysis indicated the vital role in the etiology of PCOS across ethnicities for the susceptibility loci identified in the Chinese GWAS [14]. This evidence concerns the gene DENND1A and polycystic ovary syndrome.