A type 5 adenovirus (Ad5) was engineered to specifically replicate in tumor cells by expressing Ad5-E1A under the control of a cancer-specific promoter derived from progression elevated gene-3 [32-33] and also produces MDA-7/IL-24 (Ad5-CTV) [20, 23-24, 29-30]. The gene discussed is DHTKD1; the disease is cancer.