Several research groups including our own have shown that MDA-7/IL-24 plays a tumor inhibitory role in several cancers including breast cancer [17, 20-21], prostate cancer [6, 24, 28-30, 40], melanoma [5-6, 23, 27], ovarian cancer [41-42], colorectal cancer [43-46], pancreatic cancer [47-49], non-small cell lung carcinoma [50-52], glioblastoma [53-55], hepatocellular cancers [56-57], and nasopharyngeal cancers [58]. Here, IL24 is linked to familial pancreatic carcinoma.