An increased risk of CML was also observed for individuals with haplotypes containing three rare alleles for the AVEN gene (rs7182969, rs527834, rs2632075; OR = 3.16, p < 10−3), the SEMA3C gene (rs6978637, rs10261267, rs17147989; OR = 2.75, p < 10−3), the IKBKB gene (rs11986055, rs4560769, rs6474386; OR = 2.61, p < 10−3), the GSTA3 gene (rs512795, rs2281594, rs9296695; OR = 2.12, p < 10−3), the RIPK1 gene (rs2077681, rs9392454, rs4959774, OR = 2.15, p < 10−3), and the FGF2 gene (rs3804158, rs10452197, rs308388, OR = 1.62, p < 10−3). The gene discussed is SEMA3C; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.