For instance, for the SLC15A1 gene the presence of two rare alleles with a total frequency of 14.39 % (4.72 % + 9.67 %), doubled the risk of developing CML compared to the reference haplotype (which is present in half of the general population, 47.39 %). This evidence concerns the gene SLC15A1 and chronic myelogenous leukemia, BCR-ABL1 positive.