PPARD and chronic myelogenous leukemia, BCR-ABL1 positive: This approach allowed us to identify five SNPs belonging to the PSMB10, TNFRSF10D, PSMB2, PPARD and CYP26B1 genes, which we used to create a genetic CML-risk-allele score with a high discriminating power (61%; 95% CI 58% to 64%) and a multivariate model accounting for 8.2% of the total variability observed in CML patients.