In about 10% of angiosarcomas, mutations in the VEGFR2 or VEGFR3 can be detected [8, 9], and gene expression profiling shows upregulation of TIE1, VEGFR2, SNRK, TEK (TIE2) and FLT1 (VEGFR1), all playing a role in angiogenesis. The gene discussed is KDR; the disease is angiosarcoma.