EGR3 and schizophrenia: EGR3 is regulated downstream of several key schizophrenia candidate proteins, including Neuregulin 1, N-methyl D-Aspartate Receptors (NMDARs) and calcineurin (CN) [11, 16–21], and Egr3KO mice share key phenotypes with NMDARKO and CNKO mice, including memory dysfunction and deficits in the form of hippocampal synaptic plasticity long-term depression (LTD) [4, 22, 23].