Given this limited efficacy, clinicians have turned to other therapeutics, including sorafenib and pazopanib—inhibitors of vascular endothelial growth factor A (VEGF-A) that target tumor angiogenesis—and multi-tyrosine kinase inhibitors that target platelet-derived growth factor (PDGFR)-α or VEGFR-1. Here, FLT1 is linked to neoplasm.