In order to examine whether TIC10/ONC201 along with inhibition of Bcl-2/Bcl-xL results in a mutually enhanced anti-proliferative effect, we performed MTT assays in pediatric (SF188), adult (T98G) and proneural (MGPP-3 - derived from a transgenic mouse model) glioblastoma cells. The gene discussed is BCL2; the disease is glioblastoma.