T98G glioblastoma cells treated with siRNA against DR5, the main death receptor for TRAIL in glioblastoma, showed no significant attenuation of apoptosis induced by a combined treatment with ABT263 and TIC10/ONC201 when compared to cells not silenced for DR5 (Supplementary Figure 3A and 3B). Here, TNFSF10 is linked to glioblastoma.