Among the identified transcript variants, we found a recurrent read-through fusion transcript between KLK8 and KLK7 and a novel 3′ splice site in S100A2. These were both found to be overrepresented in CRC tumor samples and cell lines when investigated in external RNA-seq datasets from TCGA, CCLE and the Illumina Human body map. This evidence concerns the gene KLK8 and neoplasm.