HDAC2 and cancer: For example, it has been repeatedly reported that some polyphenols, including OLE, are able to induce epigenetic modifications, in terms of histone acetylation and DNA methylation, particularly in cancer cells [35] and that, in the brain of OLE-fed TgCRND8 mice, modified expression levels of key proteins including glutaminyl cyclase, Beclin-1, LC-3 II and histone deacetylase-2 were found [21].