Since chemotherapeutic agents through the activation of the DDR have been shown to enhance the expression of NKG2D and DNAM-1 ligands on human multiple myeloma cells in a ROS-dependent manner [18], we investigated whether axitinib treatment could modulate the expression of the ligands for NKG2D and DNAM-1 activating NK receptors on A-498 and Caki-2 RCC lines, and the involvement of ROS signaling in this event. This evidence concerns the gene KLRK1 and renal cell carcinoma.