Exposure of RCC cells to NAC resulted in complete inhibition of MICB and ULBP1 expression in A-498 and Caki-2 cells, respectively (Figure 8A and 8B), whereas NAC pretreatment did not significantly reduce axitinib-induced increase of MICA expression on Caki-2 cells that exhibited a weaker oxidative stress response. The gene discussed is MICA; the disease is renal cell carcinoma.