As far as the mechanisms underlying axitinib-induced MICB expression, a role for Signal transducer and activator of transcription 3 (STAT3) inhibition can be envisaged based on the recent evidences demonstrating that axitinib can stimulate anti-tumor immunity by down-regulating the STAT3 expression in Renca RCC cells [54], and MICA/B expression on cancer cells induced by genotoxic stress is enhanced by inhibition of STAT3 activity [55]. This evidence concerns the gene STAT3 and neoplasm.