The expression of CD107a on NK cells from two different healthy donors contacting axitinib treated-RCC target cells, revealed that drug-treated A-498 RCC cells more efficiently triggered NK cell degranulation as compared to untreated cells, and this enhancement is completely blocked by NAC pretreatment, in parallel with inhibition of MICB induction (Figure 9). This evidence concerns the gene MICB and renal cell carcinoma.