EGFR and lung cancer: The potential role of Skp1 in lung cancer was evaluated by siRNA-mediated silencing in NSCLC lines A549 and NCI-H1975 (harboring the L858R/T790M-EGFR) [30], and the results showed that knockdown of Skp1 (Figure 1F) led to a significant inhibition of cell growth/proliferation (Figure 1G) and suppression of colony forming activity (Figure 1H, 1I) of the cells.