We tested the effects of these compounds on cancerous and normal lung epithelial cell lines, and found that three natural compounds, liriodenine, evodiamine, and 6-OAP had significant BAE to Skp1 and inhibitory effects on lung (A549, H1975 and H460), gastric (BGC823), breast (MCF7), and liver (BEL7402) cancer cell lines (Table S1). Here, SKP1 is linked to cancer.