CCNB1 and lung carcinoma: We showed that 6-OAP up-regulated pH3 and cyclin B1 and down-regulated the tyrosine-15-phosphorylated Cdc2 (pCdc2 (Y15)) in A549 and H1975 cells (Figure 4D), indicating that 6-OAP arrests lung cancer cells in an early stage of mitosis.