The cells were synchronized by double thymidine block and infected with GFP, GFP-16E2, GFP-DBD or GFP-TAD recombinant adenoviruses at multiplicity of infection (m.o.i) of 50 (these latter two constructs containing the C-terminal DNA binding domain - DBD or the N-terminal transactivation domain - TAD of the high risk HPV16 E2 protein) [18]. This evidence concerns the gene UBE2B and infection.