BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myelogenous leukemia (CML) is the poster child for TKI therapy because of the clinical success in treating this leukemia with TKIs, i.e., imatinib (IM), dasatinib, and nilotinib, which inhibit the BCR-ABL tyrosine kinase [1, 3, 13].