MAb 131-2G blocks G CX3C protein binding to CX3CR1, neutralizes RSV in vivo in an Fc dependent fashion [14,15,16] and decreases several disease manifestations in RSV challenged mice including pulmonary inflammation and mucous production, increased airway resistance after primary infection in mice, and enhanced inflammation in RSV-challenged FI-RSV vaccinated mice [14,15,18]. The gene discussed is CX3CR1; the disease is infection.