To explore effective gene therapies for GPR87-expressing cancers including urothelial cancer, and to clarify the functional role of GPR87, we constructed an adenoviral vector expressing short hairpin RNA (shRNA) targeting GPR87 (Ad-shGPR87) and confirmed its anti-proliferative effect on an GPR87-expressing bladder cell line HT1197 [11]. Here, GPR87 is linked to cancer.