Moreover, one group demonstrated that TBL1XR1 induced lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma (ESCC) via the up-regulation of VEGF-C, and may represent a novel prognostic biomarker and therapeutic target for patients with ESCC [33]. The gene discussed is TBL1XR1; the disease is esophageal squamous cell carcinoma.