Interestingly enough, even in this cohort of unaffected individuals, a clear association between the rs1205 and CRP concentrations resistant to adjustments was present in both models tested, which direction was exactly in line with the previous large community- or healthy subjects-based studies [13,14,15], supporting the above mentioned hypothesis of AS-specific effect of rs1205 on CRP levels. Here, CRP is linked to aortic valve stenosis.