In a genotype model, CRP rs1205 C>T polymorphism turned out to be associated with severe aortic valve calcification; the highest rate of subjects with severely calcified valve was present among minor homozygotes and the lowest in subjects possessing two major alleles (84.6% vs. 66.7% vs. 55.1%; p = 0.003) (Table 1, Figure 2). This evidence concerns the gene CRP and aortic valve calcification.