In our main study cohort of 300 AS patients, of the laboratory parameters of interest, i.e., fibrinogen and CRP, only the latter demonstrated a significant association with CRP rs1205 C>T polymorphism in a genotype model; CRP levels were the highest in minor homozygotes and the lowest in subjects carrying two major alleles (3.05 (2.14–4.23) vs. 2.14 (1.44–3.87) vs. 1.68 (0.98–2.90) mg/L; p < 0.001) (Table 1, Figure 1). The gene discussed is CRP; the disease is aortic stenosis.