Similar to the role of Cpr7 in [URE3] propagation, another related immunophilin FKBP52, present in brain, induces aggregation of the pathological mutant of Tau, Tau-P301L [36,57], suggesting that the role of Cpr7 in [URE3] is not an isolated example of the significance of immunophilins in amyloidosis, but is widespread in higher eukaryotes including mammals. The gene discussed is MAPT; the disease is amyloidosis.