In addition to its role in histone acetylation, CREBBP also acetylates the products of other genes that are themselves targeted by somatic alterations in B-cell lymphoma such as TP53, BCL6 and FOXO1. The TP53 gene is a well-defined tumor suppressor gene and is mutated and targeted by DNA copy number loss at a low frequency in a range of B-cell lymphomas. The gene discussed is TP53; the disease is B-cell non-Hodgkin lymphoma.