CREBBP is targeted by inactivating mutations and deletions in FL, BL and GCB-like DLBCL.10, 13, 15, 18 CREBBP associates with EP300, which is itself also mutated at a lower frequency in FL and DLBCL.10, 15 The CREBBP/EP300 complex acts to acetylate multiple lysine residues upon all four histones,43 suggesting that their mutation may have broad effects on cellular phenotypes. This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.