TP53 and acute myeloid leukemia: The tumor suppressor gene TP53, located in the commonly deleted region, 17p13, is associated with a higher degree of genomic complexity and very poor prognosis.17, 18, 19 Several studies have reported that TP53 mutations were associated with del(5q) or del(17p).20, 21TP53 alterations have been described in nearly 54–80% of MK-AML cases.22 A dysfunction in the TP53 pathway contributes to an increase in chromosomal instability.