These analyses showed greater expression of PIM1 mRNA in the FLT3-mutant (FLT3-MT) samples than in the FLT3 wild-type (FLT3-WT) AML samples in both the GSE14468 series (P < 0.001; 168 FLT3-MT samples versus 276 FLT3-WT samples) and the GSE1159 series (P = 0.002; 106 FLT3-MT samples versus 178 FLT3-WT samples) (Figure 1A). This evidence concerns the gene FLT3 and acute myeloid leukemia.