FLT3 and acute myeloid leukemia: Next we tested the effect of AZD1208 and AZD2014 on primary AML samples with either FLT3-WT or FLT3-ITD status (Table S1) under stromal co-culture conditions that used bone marrow (BM)-derived mesenchymal stem cells (MSCs) to mimic physiologic conditions [22-24].