Although the combined treatment with AZD1208 and AZD2014 caused a relative decrease of the p-4EBP1/total 4EBP1 (the lower unphosphorylated band) ratios, the amount of unphosphorylated 4EBP1 bands were also decreased in all tested cell lines and in a primary AML sample. The gene discussed is EIF4EBP1; the disease is acute myeloid leukemia.