REL and Hodgkins lymphoma: Copy number alterations have been described in HL for several loci which show corresponding transcriptional deregulation of putative target genes, including gains at 2p15 (REL), 9p24 (JAK2) and 14q22 (OTX2) and deletions at 16q12 (CYLD) and Xp21 (CYBB) [18, 37–41].