GIPR and obesity due to melanocortin 4 receptor deficiency: Surprisingly, GIPR/miceexhibit resistance to diet-induced obesity after months of high-fat feeding.More-over, the GIPR/genotype attenuates obesity in the ob/ob mouse, possiblybe-cause of reduced fat storage and altered lipid metabolism as a direct resultof absent GIP receptor (GIPR) action in adipocytes [37].