The highest ACR was significantly correlated with the age (r = 0.42), Hunt and Hess grade (r = 0.49), GCS score on admission (r = −0.49), lowest GCS score (r = −0.56), highest CRP level (r = 0.41), highest SIRS (r = 0.51), highest troponin I level (r = 0.47), ACR on admission (r = 0.77), VMACR on admission (r = 0.53), highest VMACR (r = 0.51), NT-pro-BNP level on admission (r = 0.39), highest NT-pro-BNP level (r = 0.56), mechanical ventilation duration (r = 0.53), and GOS score (r = 0.62). The gene discussed is NPPB; the disease is systemic inflammatory response syndrome.