No association of SNPs of PRM1 with male infertility was observed (OR = 1.20, 95% CI = 0.81–1.77, P = 0.358; OR = 1.19, 95% CI = 0.81–1.73, P = 0.373) and publication bias (P = 0.112; P = 0.12) did not exist in the meta-analysis. This evidence concerns the gene PRM1 and male infertility.