GO analysis showed that the genes with aberrant mRNA expression mainly took part in following biological processes (Fig. S1, Table S5): primary metabolism, cell metabolism, cell cycle progression, DNA damage and repair, biological cycle, etc. Pathway analysis of differentially expressed mRNAs (Fig. S2, Table S6) showed they were involved in the cell cycle, P53 signaling pathway, prostate cancer, thyroid cancer, and endometrial cancer, Wnt signaling pathway, glioma, bladder cancer, pancreatic cancer and axon guidance. Here, TP53 is linked to thyroid cancer.