FH and hereditary leiomyomatosis and renal cell cancer: Of all hereditary and sporadic smooth muscle tumors (n = 56), 1 uterine LM and 1 cutaneous LM from a patient with suspected HLRCC, and 2 LMS tumors were positive for 2SC, indicating the presence of an FH mutation (Table 1, Supplemental Figure 2A, 2B).