The DNA methyltransferase inhibitors 5-azacytidine and decitabine are of particular interest, where 5-azacytidine has been shown to reduce the proliferative index in an in vivo IDH1 glioma model [36] and decitabine repressed the migration capacities of Sdhb−/− cells [11]. This evidence concerns the gene IDH1 and central nervous system cancer.