However, when we plotted the ratio of H3K9me3 expression per tumor sample by dividing the expression in the chief cells by the expression in the sustentacular cells within the same tumor, thus co-opting sustentacular cells as an inter-tumor control, expression levels of H3K9me3 were significantly increased in SDH-deficient tumors compared to non-SDH mutant tumors (Figure 3E) (p = 0.01). Here, SDHB is linked to neoplasm.