Of the LM/leiomyosarcoma (LMS) tumors with an unknown FH mutation status, 1 uterine LM and 1 cutaneous LM (from a patient with suspected HLRCC), and 2 LMS tumors were positive for 2SC (Table 1, Supplemental Figure 2A, 2B). This evidence concerns the gene FH and hereditary leiomyomatosis and renal cell cancer.