In the testing cohort, serum-AFP, -CEA, -CA199, -ALB, -GGT, -ALP, tumor size, tumor number, micro-vascular invasion, TNM, and MRP8 number were predictors for OS; liver cirrhosis, serum-CEA, -CA199, -GGT, -ALP, tumor size, tumor number, micro-vascular invasion, TNM, MRP8 ratio, MRP8 number, MRP14 ratio were predictors for TTR (Supplementary Table S3). The gene discussed is S100A9; the disease is cirrhosis of liver.