Furthermore, liver cirrhosis, serum-CEA, -CA199, -GGT, -ALP, tumor size, tumor number, micro-vascular invasion, TNM, MRP8 number, MRP8 ratio, MRP14 number, MRP14 ratio, and MRP8/MRP14 ratio combination were predictors for TTR in combined primary and testing cohorts. The gene discussed is CEACAM5; the disease is cirrhosis of liver.