The decrease in BAD Ser-112 phosphorylation (Fig. 3C), along with the enhanced apoptosis (Fig. 3B) and lack of effect on cell cycle (not shown), are consistent with recent work that demonstrated that phosphorylation of BAD plays a key role downstream of JAK2 in MPN cell viability [66]. The gene discussed is JAK2; the disease is myeloproliferative neoplasm.