PCNA and Insulin resistance: In the present study, we demonstrate that feeding mice with an HFD which promoted an increase in body weight and lead to insulin resistance can result in: (i) the development of larger tumors and concomitantly into faster tumor progression; (ii) mice tumor activities of HFD mice are associated with enhanced expression levels of PCNA and pJNK; proteins related to cell growth and proliferation [8, 19].