MAPK8 and obesity due to melanocortin 4 receptor deficiency: We conclude from this study that (i) obesity induces mitochondrial dysfunction, promoting cancer in several organs adjacent to the visceral fat, such as the colon, and (ii) inhibition of the JNK/STAT3-signaling pathway in colon cancer cells seems to be critical for reestablishing mitochondrial function and overcoming the glycolytic phenotype.