Age, propensity score, year of index date, first diagnosis of any of the following post-index date: diabetes, cerebrovascular disease, coronary heart disease, peripheral vascular disease, other atheroma, atrial fibrillation, heart failure, hyperlipidaemia, hypertension, other circulatory disease, cancer, dementia, first use of any of the following post-index date: aspirin, nitrates, fibrates, b-blockers, calcium channel blockers, potassium channel activators, diuretics, positive inotropes, anticoagulants, antihypertensives, or othercardiovascular drugs. The gene discussed is KCNA3; the disease is peripheral vascular disease.