Tumor cells derived from one of the two TrkA IHC+ CRC patients were sensitive to a potent pan-TrkA inhibitor, entrectinib, with inhibition of downstream pathways, suggesting that NTRK1 rearrangements in non-lung or non-thyroid cancer can be a potent actionable genetic aberration as in NSCLC [18]. Here, NTRK1 is linked to non-small cell lung carcinoma.