Inducible nitric oxide synthase, an enzyme that catalyses the production of nitric oxide from L‐arginine upon stimulation by pro‐inflammatory cytokines (e.g., IL‐1, tumour necrosis factor α and interferon γ), has been suggested to participate in host immunity and anti‐microbial and anti‐tumour activities as part of the oxidative burst of macrophages 76. The gene discussed is IL1B; the disease is neoplasm.