PDX1 and familial pancreatic carcinoma: To investigate the localization and dynamics of E-cadherin in pancreatic cancer cells, PDAC tumor cells isolated from Pdx1-Cre, LSL-KRasG12D/+, Trp53LoxP/+ mice (Morton et al., 2010b) were stably transfected with GFP-chimeras of wild-type E-cadherin or mutants.