MDM4 and breast carcinoma: After stratifying according to MDM2 SNP309 status, we found a reduced risk for breast cancer among individuals harboring the MDM4 SNP34091CC/MDM2 SNP309GG genotype, and this association was stronger after removing individuals harboring the MDM2 SNP285C allele, previously shown to antagonize SNP309G‐induced transcription elevation 16.