This domain is 45 % homologous to the one predicted in FAM111A [MIM 615292], in which causative mutations have been recently reported to cause the Kenny-Caffey syndrome (KCS [MIM 127000]) and osteocraniostenosis (OCS [MIM 602361]), two clinical entities phenotypically distinct from POIKTMP [17]. This evidence concerns the gene FAM111A and Kenny-Caffey syndrome.