In experimental data, using a diet-induced obesity model, Poncelas et al. [32] suggested the beneficial effect of increased insulin signaling as the mechanism underlying the obesity paradox, and Salie et al. [33] reported that obesity-inducing diets appeared to have a cardioprotective effect against ischemia or reperfusion damage. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.