CASP8 and Lymphadenopathy: Specific deletion of caspase-8 in myeloid cells (CreLysMCasp8fl/fl) leads to the development of a mild systemic inflammation characterized by splenomegaly, lymphadenopathy, immune complex deposition in the kidney, proteinuria, hypergammaglobulinemia, and elevated amounts of serum cytokines that is preventable by RIPK3 deletion.