Specific deletion of caspase-8 in myeloid cells (CreLysMCasp8fl/fl) leads to the development of a mild systemic inflammation characterized by splenomegaly, lymphadenopathy, immune complex deposition in the kidney, proteinuria, hypergammaglobulinemia, and elevated amounts of serum cytokines that is preventable by RIPK3 deletion. This evidence concerns the gene CASP8 and Splenomegaly.